The cells are separated by a physical barrier, called basal lamina, which underlies layers of epithelial cells as well as surrounds endothelial cells. The cancer cells become matastatic and their basement membrane is being distorted and they escape from the original tissue, invade adjoining tissues and finally through circulation spreads throughout the body. Again they [...]
Carcinogenesis appears to be linked with autogenesis, because, the aberrations in the cancer cell is heritable and have shown to share abnormality in their DNA sequences. The chemical mutagen and X-ray induce aberrations and local changes in DNA that led into cancer. In normal human beings, in their lifetime, an estimated 1016 cell divisions take [...]
It is fact that one transformed cell is enough to produce a cancer, i.e., the cancerous cells are indeed a clone discended from a single abnormal cell. It can be easily proved when the leukemic white blood cells of chronic myeloid leukemia are observed that all have a specific chromosomal abnormality where translocation between chromosome [...]
The older animals and humans have some localized growth of tissue, having cells that are closely resembled and function like normal cells. The cell adhesion and interaction molecules hold together is called the tumor of benign type. As they are surrounded by the fibrous tissues and remain stay in their original place they can be [...]
1. Changes in glycosidation of lipids and proteins: The Golgi complex plays a central role in the biosynthesis of gangliosides and other glycosphingo lipids. There is evidence that in cancer cells, there are surface membrane changes that involve a loss of glycosphingo lipids and these alterations are due to the reduction of one or more [...]
