It is fact that one transformed cell is enough to produce a cancer, i.e., the cancerous cells are indeed a clone discended from a single abnormal cell.
It can be easily proved when the leukemic white blood cells of chronic myeloid leukemia are observed that all have a specific chromosomal abnormality where translocation between chromosome 9 and 22 has taken place. The smaller of the two aberrant chromosomes is called the Philadelphia chromosome.
From many evidences it has been concluded that most cancers originate from a single aberrant cell which has arisen from a unique accident.
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- cancer cell characteristics
Tags: cancer